After reviewing this tutorial, participants should be able to discuss the methods of production of isotopes for medical and general commercial use
Should be able to define the term "radiopharmaceutical" and to list the properties of the ideal diagnostic and ideal therapeutic radiopharmaceutica
Should be able to distinguish between the terms "radiopharmaceutical" and "radiochemical"
Should be able to discuss the properties common to all injectable drugs
Should be able to state the regulation covering legal limits for calibrated doses compared to prescribed doses
Should be able to list several examples of dynamic and static studies as well as in vivo non-imaging studies
Should be able to identify the imaging procedures/target organs associated with every radiopharmaceutical used in the United States, including several INDs
Should be able to give the typical administered dose for each of these drugs and the route of administration
Should be able to describe the kinetics of most of these drugs, including routes of excretion of the more commonly used radiopharmaceuticals
Should be able to describe the stannous reduction method
Should be able to describe a hexacoordinated Tc complex and draw its octahedral structure; and should be able to identify special patient preparations and restrictions used for several commonly used radiopharmaceuticals
Should be able to list and give examples of the 6 classical mechanisms of localization of radiopharmaceuticals as well as some of the mechanisms associated with the newer radiopharmaceuticals
Should be familiar with uptake ratios and excretion rates, e.g., the percentage of each of the 5 renal imaging agents cleared by filtration and secretion as well as the amount bound to the tubules
Should be able to describe an antigen-antibody reaction and the part it plays in the uptake of radiolabeled monoclonal antibodies by specific types of malignant tumors
Should be able to state legal particle size requirements for those preparations containing labeled particles.