2 HRS SNM/VOICE CEU
  

A Tutorial by Stephen M. Karesh, PhD


Adapted for the Web by Stephen M. Karesh, PhD & Marsha Lipps CNMT

This Tutorial Gives Special Thanks To:

Spectrum Pharmaceuticals, Inc.: Zevelin

GlaxoSmithKline: Bexxar

Biogen idec

Genentech Biooncology

CTI- Cell Therapeutics, Inc


Mike Wakefield Pharm.D.


Bobbie Miller BS CNMT
ZEVALIN: IMAGING OF 111 IN ZEVALIN

111 In Zevalin Imaging: Purpose

• To verify the expected biodistribution
• R/O rare cases of altered biodistribution
• Not to diagnose the extent of NHL

Data Acquisition for 111 In Zevalin

• Dual or single head gamma camera system
• Medium energy collimator(s)
• 172 and 247 keV with 15% window
• 256 x 1024 matrix
• Speed (dependent on time after injection)
• 10 cm/min (20 minute scan) at 2 - 24 hours
• 7 - 10 cm/min (30 minute scan) at 48 - 72 hours
• 5 - 7 cm/min (40 minute scan) at 90 - 120 hours (optional)

Expected Biodistribution

Anterior Posterior Anterior
Posterior
 Anterior Posterior
4-6 Hrs
64-70 Hrs
138-142 Hrs


Representative Patient: 111 In-Labeled Zevalin® Monoclonal Antibody Imaging

4 hour
66 hour
139 hour


Abdominal SPECT


Abdominal CT

 

Altered Biodistribution Image


Median 90 Y Zevalin Radiation: Absorbed Doses to Organs and Tumor


 

 
 
 

 


 

TUTORIAL NAVIGATION

  
 

April 4, 2010