Zevalin Administration Equipment

• 10 mL syringe for 0.9% NS
• Low protein binding 0.22 micron filter
• Syringe shield
• 0.9% Normal Saline

Zevalin Administration

Patient preparation: In order to minimize the likelihood of an allergic reaction to a foreign protein, the patient receives 650 mg of Tylenol and 50 mg of Benadryl orally at least 30 min before administration of the cold non-radioactive antibody (Rituxan) used to block non-specific binding sites.

• Establish venous access with butterfly needle or angiocath attached to IV tubing and 250 mL of 0.9% normal saline bag
• Flush venous line with10 mL of 0.9% NaCl to reconfirm patency
• Stop flow from IV bag
• Pre wet 0.22 micron filter with NaCl 0.9%
• Place a 0.22 micron (low protein binding) filter between the stopcock and injection port
• Slowly inject Y-90 over ten minutes
• Slowly flush line with at least 10 mL of 0.9% NaCl after injection is completed
• DO NOT Bolus