Principles of Radioimmunotherapy

● Targeted delivery of radiation
● Greater exposure of tumors vs. surrounding organs by virtue of the selectivity of the carrier antibody
● Potential for continuous exposure of tumor cells
● Anti-tumor mechanisms of the antibody
Juweid ME. J Nucl Med 2002;43:1507-1529. Kaminski MS et al. Blood 2000;96:1259-1266.

Rationale for Radioimmunotherapy of Lymphoma

● High sensitivity of lymphomas to radiation
● Abundant and well-characterized surface antigens
● Multiple MAbs available
● Promising clinical results with unconjugated antibodies (Rituximab)