After reviewing this tutorial, the user should be able to list the various types of impurities found in the eluate collected from the Mo-99/Tc-99m generator and give an example of each; should be able to identify the various classes of impurities found in radiopharmaceuticals and give an example of each; should be able to describe in detail how QC testing is performed on the eluate and on Tc-99m radiopharmaceuticals; should be able to state the specifications for each of these tests and what action is required if there is a test failure; should be able to list the 4 QC tests performed on a dose calibrator and required frequency of performance; should be able to describe how each test is performed, state the legal specification, and describe the action required if there is a test failure; should be able to state the difference between agreement states and non-agreement states; should know the basics of licensure by the NRC and State regulatory agencies; should be able to list the various requirements for maintaining log books in the lab and the required frequency of entry; should be familiar with basic rules of radiation safety, e.g., to describe what precautions and action must be taken when there is a spill or contamination is found on a technologist's hands; and should be able to define "misadministration" according to the new rules, and to state what one must do to document and report the occurrence.

● RATIONALE FOR PERFORMING QUALITY CONTROL: For certain procedures, IT'S THE LAW.

■ Non-Diagnostic Study ==> Procedure must be repeated; increased radiation dose and patient discomfort; delayed diagnosis

● CRITERION: You must be able to answer "yes" to the question, "Would I inject this into my mother?"

● Impurities

Classification
Detection of Impurities

● QC Testing of a Mo/Tc Generator

Frequency Specifications
QC Test Procedures for Mo/Tc Generator

■ Mo-99 Breakthrough
■ Aluminum Ion Breakthrough
■ Free Tc

● QC Testing in Radiopharmaceuticals

Types of Impurities
Thin Layer Chromotography Systems of Tc-99m Compounds.
Tc-99m Chromotography: Separation on Strip
Thin Layer Chromotography Systems:Tc-99m Hepatobiliary Agents
Exceptions
Strip Design
Migration Patterns of Tc-MDP

● Quality Control Of Dose Calibrators

Frequency Specifications

■ Geometry
■ Accuracy
■ Constancy
■ Linearity

Specifications: Dose Calibrator QC Tests
Full Width Half-Maximum Value