3 HRS SNM/VOICE CEU
 

 


HOT LAB QUALITY CONTROL

1. Radioisotope Dose Calibrators

DOSE CALIBRATORS
The current NRC regulations no longer mention the accuracy, constancy, linearity, and geometry tests. According to 10 CFR Part 20 Section 35.60, a licensee shall calibrate the radioisotope dose calibrator in accordance with nationally recognized standards or the manufacturer’s instructions. The bottom line: current manufacturers’ recommendations are identical to the old NRC regulations so our requirements for the accuracy, constancy, linearity, and geometry tests are annually, daily, quarterly, and at installation, respectively.

Deviation from standard or expected values for all dose calibrator tests must be within ± 10%. If Deviation >10%, then obligation is to record value, note repair or recalibration of instrument, retest, and record new values. In addition to the above steps, every dose must be corrected mathematically until the instrument is repaired. There is NO LONGER a reporting requirement.

The accuracy test is performed at installation and annually. It is designed to show that the calibrator is giving correct readings throughout the entire energy scale that we are likely to encounter. Low, medium, and high energy standards (usually Co-57, Ba-133 or Cs-137, and Co-60, respectively), are measured in the dose calibrator using appropriate settings. Standard and measured values are compared.

This accuracy test is a pass:

Standard Energy (keV) expected value (mCi) measured value (mCi)
Co57
122
2.48
2.51
Cs137
662
3.38
3.29
Co60
1,332
1.55
1.52


The constancy test is performed at installation and daily. It measures instrument precision and is designed to show that a long-lived source, usually 30 y Cs-137, yields reproducible readings on a daily basis on all isotope settings we are likely to use. The Cs-137 source is placed in the dose calibrator. Activity is then measured on the Cs-137 setting and all other settings used on a daily basis. Values are recorded in the dose calibrator logbook and are compared with recent values to determine if instrument is maintaining constancy on a daily basis.

This constancy test is a pass:

ISOTOPE READING (mCi)
SETTING MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY
Cs137 123 124 122 126 124
Ga67 223 224 222 224 226
Tl201 163 164 162 166 164
Tc99m 243 242 244 246 244
I131 313 314 312 316 314
I123 193 192 194 196 194
In111 283 284 282 286 284
Xe133 433 434 432 436 434


The linearity test, performed at installation and quarterly, is designed to prove that the dose calibrator readout is linear for sources varying from the mCi range through the mCi range. A high activity Tc-99m source (50-300 mCi) is measured at T0 and at predetermined time intervals up to 72 hours. Expected and actual measurements are compared (and may be analyzed graphically) to determine if the instrument is linear throughout the activity range we are likely to encounter.


This linearity Test is a Pass:

Elapsed time
Expected reading
Measured reading
(hr)
(mCi)
(mCi)
0
300
300
1
267
272
2
238
241
3
212
209
6
150
148
12
75
72.4
24
18.75
19.1
48
1.17
1.19
72
0.073
0.074
78
0.036
0.037



The Geometry Test, performed at installation, is designed to show that correct readings can be obtained regardless of the sample size or geometry. 0.5 ml of Tc-99m in a 10 ml syringe (activity 25 mCi) is measured in the dose calibrator and the value obtained is recorded. The activity is then diluted with sterile water to 1 ml, 2 ml, 3 ml, 4 ml, etc. At each of these points a reading is taken and the value recorded. Data are then evaluated to determine the effect of sample geometry on the dose calibrator reading. If instrument is geometry-dependent, it may be necessary to routinely correct readings obtained when using calibrator.

geometry

This Geometry Test is a Pass:

Sample Volume Activity (mCi)
0.5
25.5
1.0
25.3
2.0
25
3.0
24.8
4.0
24.7
5.0
24.5
6.0
24.3


 

 

 

 

 


 

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February 12, 2010